Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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ANALYSIS OF IL10 GENE EXPRESSION IN DECIDUAL AND CHORIONIC TISSUES AT PREGNANCY LOSS

Mashkina E.V. 1 Kovalenko K.A. 1 Miktadova A.V. 1 Volosovcova G.I. 1 Saraev K.N. 1
1 Southern federal university
Deregulation of the cytokine functional network is a risk factor of early pregnancy disorders. IL-10 is a key regulator of the immune response that inhibits the secretion of proinflammatory cytokines. In this work the frequency of registration of polymorphism -819C-T gene IL-10 was analyzed in the cells of the decidua and chorionic tissue miscarriage in the first trimester. The differences in allele and genotype frequencies were compared with the control is not revealed. However, the level of IL-10 gene expression in the decidual tissue was significantly higher at pregnancy loss with comparison to the decidua and chorionic tissues at physiological developing pregnancy. Since cytokines are mediators of cell-cell interactions change in the functioning of genes cytokine network involves a change in the regulation of expression and function of a number of metabolic cascades.