Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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DYNAMICS OF THE MORPHOLOGICAL STATUS DERMIS IN RESPONSE TO THE HYDROXYAPATITE CRYSTALS

Mogilnaya G.M.,Fomicheva E.V. 1 1
1 Kuban State Medical University
The morphological transformations which took place in the dermis in the area of injections of the drug “Radiesse” are analyzed in the experiment. The drug was injected to male rats in the volume of 0.05 ml. Evaluation was carried out at 2,4,6,8, and 16 weeks of the experiment. The morphology of the components of dermis was studied in the slides stained with hematoxylin and eosin, and Weigert and Vangizon method. The morphology of microspheres was held and also was estimated it’s optical density. Investigation showed that the first cells that responded to “Radiesse”, were macrophages and fibroblasts (2nd week) . Later (4th week) wasobserved the transformation of macrophages into osteoclasts and activation of collagen synthesis by fibroblast. The microspheres flattened, their size increased , and the optical density reduced. The microbicide status of neutrophils didn’t change at all stages of observation.