Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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RADIOSENSITIVITY OF T-LYMPHOCYTES IN OFFSPRING OF FATHERS CHRONICALLY EXPOSED TO IONIZING RADIATION

Ahmadullina Y.R. 1, 2 Akleev A.V. 2, 1
1 Chelyabinsk State University
2 Urals Research Center for Radiation Medicine
Presented in this paper are the results of a research into the effects of chronic radiation exposure of the fathers’ gonads (the individual doses in the year of the conception of the children ranged from 0.003 to 0.5 Gy) on the radiosensitivity of peripheral blood lymphocytes in a group of first-generation offspring (the mean age as of the year of the study was 40 years). The results indicated that the spontaneous frequency of lymphocytes with micronuclei in the group of offspring did not differ from that estimated for the group of their fathers, and for the group of unexposed age-matched offspring. A statistically significant decrease in the frequency of lymphocytes with micronuclei following in-vitro irradiation of a cell suspension at a dose of 1 Gy was observed in the group of offspring as compared with the controls (p=0.002). However, neither the spontaneous frequency of lymphocytes with micronuclei, nor the frequency of lymphocytes with micronuclei displayed after in-vitro exposures at doses of 1Gymanifested any dependence on the fathers’ gonadal doses in the year of conception.