Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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EXTRACTS OF BASIDIOMYCETES SUPPRESS REPRODUCTION OF THE VIRUS OF BIRD FLU A(H5N1) IN EXPERIMENTS IN VITRO AND IN VIVO

Filippova E.I. 1 Kabanov A.S. 1 Skarnovich M.O. 1 Mazurkov O.Y. 1 Teplyakova T.V. 1 Kosogova T.A. 1 Makarevich E.V. 1 Ibragimova Z.B. 1 Troshkova G.P. 1 Shishkina L.N. 1 Mazurkova N.A. 1
1 State Research Center of Virology and Biotechnology Vector
Aqueous extracts of higher fungi basidiomycetes Laetiporus sulphureus, Ganoderma applanatum и Inonotus obliquus were investigated with respect to antiviral activity for cell culture MDCK and mice Balb/c. All investigated specimens fungal extracts reduced the infectivity of virus of bird flu strain A/chicken/Kurgan/05/2005 (H5N1) in MDCK cells about 4,0 - 5,5 lg, that was comparable with the use of Tamiflu® in these experiments. In experiments in vivo in medical scheme by per oral administration of basidiomycetes Inonotus obliquus and Laetiporus sulphureus extracts to mice infected with the bird flu strain A/chicken/Kurgan/05/2005 (H5N1) there is a reduction of its products in the lungs of animals. The largest compared with the control of authentically authentically reducing the virus concentration in lung homogenates was observed in mice treated with basidiomycete Inonotus obliquus extract (09-24), that was 1,95 lg. When assessing the survival, coefficient of protection and average life expectancy (ALE) of mice in the experimental and control after their infection with highly pathogenic bird flu virus it is established that for all three indicator the greatest protective effect on the infected mice found extract Inonotus obliquus (09-24), that was comparable with that of the commercial antiflu drug Tamiflyu®.