Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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ANTIVIRAL PROPERTIES OF AQUEOUS EXTRACTS ISOLATED FROM HIGHER BASIDIOMYCETES AS RESPECT TO PANDEMIC INFLUENZA VIRUS А(ШШ)2009

Filippova E.I. 1 Mazurkova N.A. 1 Kabanov A.S. 1 Teplyakova T.V. 1 Ibragimova Z.B. 1 Makarevich E.V. 1 Mazurkov O.Y. 1 Shishkina L.N. 1
1 State Research Center of Virology and Biotechnology Vector
Aqueous extracts of higher fungi basidiomycetes Laetiporus sulphureus, Ganoderma applanatum и Inonotus obliquus were investigated with respect to their toxicity and antiviral activity for cell culture MDCK and mice Balb/c. All investigated specimens fungal extracts were low-toxic for cell culture MDCK and laboratory animals. Fungal extracts reduced the infectivity of pandemic influenza virus strain А/Moscow/226/2009 (H1N1)v in MDCK cells about 2,69 - 3,22 lg, that was comparable with the use of Tamiflu® (the suppression of reproduction of the virus was 2,90 lg). In experiments in vivo by per oral administration of basidiomycetes extracts to mice infected with the pandemic influenza virus strain А/Moscow/226/2009 (H1N1)v there is a reduction of its products in the lungs of animals. 4 days post infection the virus concentration in lung homogenates of animals treated with basidiomycetes Inonotus obliquus и Laetiporus sulphureus extracts was authentically lower than control on 1,83 and 2,00 lg respectively; for mice treated with Tamiflu® the reduction of the virus concentration in comparison with the control was 2,16 lg.