Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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TISSULAR SYSTEM OF ACTIVATION OF PLASMINOGEN WITH SKIN MELANOMA

Frantsiyants ЕЖ. 1 Komarova ЕЖ 1 Pozdnyakova V.V. 1 Pogorelova Y.A. 1 Cheryarina N.D. 1 Kozlova L.S. 1 Khokhlova O.V. 1
1 Federal state budget-funded institution of the Ministry of Health of Russia «Rostov scientific and research institute of oncology»
The level of plasmin, plasminogen, and plasminogen activators (urokinase uPA and tissue tPA activators of plasminogen) in cytosolic fraction has been studied in 40 samples of tissue taken from skin melanoma рТ1-4N0-ХM0, its perifocal area and along the resection line. The results obtained indicate that the connection between components of tissular fibrinolytic system and skin melanoma progressing is true. They also show that components of plasminogen activation system have pathogenetic meaning for growth and development of skin melanoma and they may be a target in target therapy. They allow considering resection limits with skin melanoma, as surgical interference in the metabolically changed tumor field around it may foster emergence of both local and remote metastases.