Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE AND THIOTRIAZOLIN INFLUENCE ON PROTEOLYSIS IN BRAIN TISSUE AFTER CHRONIC ALCOHOL INTOXICATION

Khodos O.A. 1
1 Vitebsk state medical university (210000
The influence of ethylmethylhydroxypyridine succinate and thiotriazolin on proteolysis in brain tissue extracts (cerebral hemispheres and cerebellum tissue) in rats at withdrawal after chronic alcohol intoxication was studied. The activity of proteinases and their endogenous inhibitors in cerebral hemispheres and cerebellum tissue was studied spectrophotometrically. The substrate was N-a-benzoyl-D,L-arginine-p-nitroanilide (BAPNA). It was obtained that chronic alcohol intoxication is accompanied by disordes of the balance of activity of proteinases and their endogenous inhibitors and severe hemodynamic disordes in the brain microcirculatory bed, increase of metabolic and irreversible dystrophic disturbances of atrophic (kario- and cytopicnosis) and (kario- and cytolisis, kariorheksis) necrotic character. Ethylmethylhydroxypyridine succinate and Thiotriazolin normalize activity of proteinases and their endogenous inhibitors in cerebral hemispheres and cerebellum tissue. Use of ethylmethylhydroxypyridine succinate and Thiotriazolin leads to decrease of destructive changes due to their vaso- and neuroprotective influence resulting from their positive effect on brain tissue metabolism and microcirculation.