Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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EVALUATION OF EFFICIENCY OF ANTIOXIDANTS DIHYDROQUERCETIN AND MEXICOR® IN COMPLEX THERAPY OF DIFFUSE PERITONITIS IN EXPERIMENTAL STUDY

Chmykhova A.N. 1 Artyushkova E.B. 2 Sein O.B. 1 Artyushkova E.V. 2
1 Kursk State Agricultural Academy named Professor I.I. Ivanov
2 Kursk State Medical University
The present experimental study demonstrated that Dihydroquercetin (7,7 mg/kg a day) and drugs such as Mexicor® (60 mg/kg a day) and Galavit® (8,6 mg/kg a day) exert the beneficial effects on oxidant-antioxidant status, proinflammatory cytokines levels and NO-producing function of endothelium due to the diffuse peritonitis modeling. The most pronounced protective effect was obtained with the combined administration of Dihydroquercetin with Galavit® and Mexicor® with Galavit®.The data presented in this study suggest that monotherapy by Dihydroquercetin, Mexicor® and Galavit® also have the positive protective effect on morphological changes and increase the regional blood flow level in the intestinal wall relative to the control. Dihydroquercetin has a strong antioxidant effect which was comparable to the combined administration of Dihydroquercetin with Galavit® and Mexicor® with Galavit®. Estimation of total mortality in experimental animals caused by modeling diffuse peritonitis represents the efficiency of pharmacological action of the test drugs and their combinations in the following sequence: reduction of the total mortality by 16% (Galavit®), 22% (Mexicor®), 28% (combined administration of Mexicor® with Galavit®), 30% (Dihydroquercetin) and 36% (combined administration of Dihydroquercetin with Galavit®).