Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

INVESTIGATION OF LACTULOSE SYRUP ANTIOXIDANT ACTIVITY IN MODELS OF OXIDATIVE PROCESS WITH THE USE OF CADMIUM CHLORIDE

Budkevich R.O. 1 Gatina J.S. 1 Budkevich E.V. 1
1 FSAEI HPE “North-Caucasus Federal University”
In this study the antioxidant activity of lactulose from different manufactures was investigated. Cadmium chloride was used for modeling of oxidative stress in vitro and in vivo. Antioxidant activity of lactulose samples in vitro was different. It was detected the sample of lactulose which increase to the maximum level of antioxidant activity in cadmium contaminated raw-milk. Molecular weight of components in the lactulose syrup with the highest antioxidant activity was determined by dialysis bag experiment. The highest manifested antioxidant activity corresponded to components with molecular weight between 3.5 and 6-8 kDa. Lactulose syrup with the highest and the lowest antioxidant activity was administrated for rats during 1 months. The best effect of lactulose syrup in vivo was showed by that sample, which showed the best antioxidant activity in the model reactions. The results suggest using lactulose syrup with components of isomerization (molecular weight 3.5 - 6-8 kDa) as an antioxidant component in a functional food.