Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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HEREDITARY PREDISPOSITION CLINICAL AND MORPHOLOGICAL FEATURES OF BREAST CANCER FROM RESIDENTS OF KABARDINO-BALKARIA

Bittueva M.M. 1 Bogotova Z.I. 1 Daurova L.V. 1 Gidova E.M. 1 Paritov A.Y. 1 Handohov T.H. 1 Sitnikov M.N. 1 Kerefova M.K. 1
1 Kabardino-Balkarian State University n.a. H.M. Berbekov
Research on individual genotyping of healthy and sick women in Kabardino-Balkar Republic for definition of groups of risk with the increased predisposition of development of a hereditary form of a breast cancer is conducted. The analysis of distribution of frequencies of alleles and genotypes of polymorphic options of genes, and also associations of genotypes with possible risks of development of a breast cancer is carried out. Samples of blood are collected and DNA more than 300 people (control and skilled group) is allocated. On this selection cases of a carriage of mutations of a gene 6174delT a gene of BRCA2 and mutations 5382insC and 4154delA BRCA1 gene at women, patients with cancer of a mammary gland are revealed. The obtained data give the chance to draw a conclusion on establishment of hereditary forms of a breast cancer. Carrying out the comparative analysis of frequencies of alleles of genes of predisposition to a hereditary form of this disease will give the chance to open the genetic reasons of increase in cancer diseases and to define groups of the greatest risk.