Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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HEREDITARY PREDISPOSITION CLINICAL AND MORPHOLOGICAL FEATURES OF BREAST CANCER FROM RESIDENTS OF KABARDINO-BALKARIA

Bittueva M.M. 1 Bogotova Z.I. 1 Daurova L.V. 1 Gidova E.M. 1 Paritov A.Y. 1 Handohov T.H. 1 Sitnikov M.N. 1 Kerefova M.K. 1
1 Kabardino-Balkarian State University n.a. H.M. Berbekov
Research on individual genotyping of healthy and sick women in Kabardino-Balkar Republic for definition of groups of risk with the increased predisposition of development of a hereditary form of a breast cancer is conducted. The analysis of distribution of frequencies of alleles and genotypes of polymorphic options of genes, and also associations of genotypes with possible risks of development of a breast cancer is carried out. Samples of blood are collected and DNA more than 300 people (control and skilled group) is allocated. On this selection cases of a carriage of mutations of a gene 6174delT a gene of BRCA2 and mutations 5382insC and 4154delA BRCA1 gene at women, patients with cancer of a mammary gland are revealed. The obtained data give the chance to draw a conclusion on establishment of hereditary forms of a breast cancer. Carrying out the comparative analysis of frequencies of alleles of genes of predisposition to a hereditary form of this disease will give the chance to open the genetic reasons of increase in cancer diseases and to define groups of the greatest risk.

Библиографическая ссылка

Биттуева М.М., Боготова З.И., Даурова Л.В., Гидова Э.М., Паритов А.Ю., Хандохов Т.Х., Ситников М.Н., Керефова М.К. НАСЛЕДСТВЕННАЯ ПРЕДРАСПОЛОЖЕННОСТЬ И КЛИНИКО-МОРФОЛОГИЧЕСКИЕ ОСОБЕННОСТИ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ У ЖИТЕЛЬНИЦ КАБАРДИНО-БАЛКАРИИ // Научное обозрение. Биологические науки. 2015. № 1. С. 39-39;
URL: https://science-biology.ru/en/article/view?id=224 (дата обращения: 08.05.2026).