Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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COMPARATIVE EVALUATION OF HEPATOPROTECTIVE PROPERTIES OF PHARMACOLOGICAL PREPARATION «PHOSPHOGLIV», LINSEED OIL, EASTERN BLACK WALNUT AND WALNUT OILS

Esaulenko E.E. 1
1 Kuban State Medical University
In experiment in male rats have been studied hepatotropic effects of pharmacological preparation “Phosphogliv”, linseed oil, eastern black walnut and walnut oils, rats liver toxicity modeled by administering carbon tetrachloride. Functional condition of liver was assessed by activity of aspartate aminotransferase, alanine aminotransferase, γ -glutamyltranspeptidase, alkaline phosphatase in the blood of animals and concentrations of total and direct bilirubin in serum. In rats with CCl4 intoxication significantly increased activity of transaminase, γ-glutamyl and increased blood levels of bilirubin due to its direct fractions, indicating that the formation of the animals’ syndromes of intrahepatic cholestasis and cytolysis. Histological study of liver tissue showed significant pathological changes in the structure of the organ. There were signs of karyolysis, focal necrosis, fatty degeneration of hepatocytes, as well as stasis microcircular, erithrodiapedez, perivascular polymorphocellular infiltrates. In rats with toxic liver treated with “Phosphogliv” or tested oils was significantly decreased activity of transaminase, γ - glutamyl and bilirubin in the blood, as compared to animals receiving test no substances. Histological examination of liver tissue of rats with CCl4 intoxication was found that the administration of the test substances to them contributed to the recovery of the morphological structure of the liver. The results allowed concluding that the test substances have significant hepatoprotective properties whose expression in a comparative series is as follows: “Phosphogliv”, linseed oil, eastern black walnut oil, walnut oil.