Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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REMODELING OF CHROMATIN STRUCTURE AND CHANGE THE PHENOTYPE OF NEUTROPHILIC GRANULOCYTES INFLUENCED G-CSF IN PATIENTS WITH COLORECTAL CANCER

Nesterova I.V. 1 Kovaleva S.V. 2 Evglevckiy A.A. 2 Chudilova G.A. 2 Lomtatidze L.V. 2 Fomicheva E.V. 2
1 Peoples’ Friendship University of Russia
2 Kuban State Medical University
The experiment studied in vitro correlation of expression of membrane receptors CD16, CD32 and CD11b neutrophil granulocytes (NG) in patients with colorectal cancer (CRC) and the level of restructuring their chromatin under cell stimulation G-CSF. It is shown that G-CSF has a significant normalizing (modulating) the effect on the level of chromatin restructuring NG patients with CRC and its correlation with the expression of receptors relations CD16, CD32. At the same time, while maintaining a positive modulating effect on the level of chromatin restructuring NG G-CSF exacerbates the nature of the correlations of this parameter with respect to receptor expression CD11b.