Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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EFFECT OF IMMUNIZATION ON THE HUMORAL AND CELLULAR IMMUNE RESPONSES RATS EXPOSED IMMOBILIZATION STRESS WITH ORIGINALLY DIFFERENT RESISTANCE TO HYPOXIA

Komelkova M.V. 1
1 South Ural State Medical University Russian Federation
When animals were immunized with heterologous antigen was found that the initial sensitivity to hypoxia significantly affect the severity of cellular and humoral immunity. The obtained results allow to conclude that the low resistant immunized, but not immobilized rats have higher levels of humoral and cellular immune responses. This is confirmed by the high content of antibody cells and the intensity of delayed-type hypersensitivity. It can be assumed that no animals immobilized with quality lower level of immune response is associated with quantitative redistribution of cells in hematopoiesis and shifted toward erythropoiesis. Under the influence of stress factor in rats with hypoxia resistant to an increased level of Th-2 immune response, while reducing the level of erythropoiesis. At low resistant stressed animals after immunization tended to decrease the amount of antibody cells. This may be related to the low level of cytokines and with reduced sensitivity to them.