science-review.ru
Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454
ISSN 2500-3399
ПИ №ФС77-57454
STABILIZATION OF THE ENZYME CLASS OF PROTEASES IN BIOPOLYMER STRUCTURE MATERIALS
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Fundamentally new film materials undergoing self-biodegrade in natural conditions. Optimal composition for biodegradable films have advantages: transparency, flexibility, strength of the structure with tensile strength. Held immobilized enzyme preparations in the structure of biodegradable plastic materials with high rates of saving specific activity. First obtained film coatings with immobilized enzyme lysozyme, which can be used as wound dressings in medicine and cosmetology. Showed the presence of two fractions, labile and stable, immobilized samples. Found that the maximum fall of proteolytic activity of the resulting materials is in the process of drying. The most widely used in clinical practice are proteolytic enzymes. Therefore, much research is devoted to obtaining their immobilized derivatives. Development of new processes based on biocatalysts immobilized in the structure of different nature, open the way not only new materials, but also contribute to the improvement of existing ones. Preservation of the activity and stability of biological substances (eg enzymes) in time due to the need to create biospecific frameworks and methods of incorporating biological agents in the structure of the carrier material. The existing materials as a basis to the immobilized enzymes used fabric material, collagen. All require disposal of waste material. Their lack of transparency does not allow follow the processes of wound healing. Step process of healing requires constant change povyazochnogo material with different enzyme preparations, depending on the type of wound. Thus, there is a need for new and improved universal existing bioactive materials with predictable lifesaving activity prolongated effect and biodegradability.