Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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THE FUNCTIONAL CONDITION OF THE ARCUATE NUCLEUS OF THE HYPOTHALAMUS IN THE DIMANICS OF TOXIC STRESS CAUSED BY CADMUIM SALT

Muratova N.R. 1 Kotelnikova S.V. 1
1 Astrakhan state technical university
The morphofunctional state of hypothalamic arcuatus nucleus of white rats’ males and females in the conditions of intoxication development and after its termination was studied. An intoxication caused daily enteral introduction a cadmium chloride solution calculating 2 mg/100 g of a body’s animal weights. Experimental groups with duration 5, 10 and 15 days of cadmium salt introduction, and also with duration 5, 10 and 15 days of the regenerative period after the termination of a 15-day intoxication were formed. Introduction of cadmium chloride led to decrease nucleus volumes of neuroendocrinocytes at both males and females, and its cancellation led to their recovery to values proper to control animals. Thus more expressed suppression of the functional state of the neuroendocrine centre on receipt of cadmium salt was at males in an initial stage of the intoxication and more effective restoration to base values was at them after the termination toxic introduction.