Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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STUDY THE EFFECT OF MELATONIN ON THE PROLIFERATION AND AN INDUCTION OF THE DIFFERENTIATION OF MOUSE N1E-115 NEUROBLASTOMA CELLS

Myakisheva S.N. 1 Krestinina O.V. 2
1 Institute of Cell Biophysics of RAS
2 Institute of Theoretical and Experimental Biophysics of RAS
Melatonin plays an important role in many physiological processes. Antiproliferative, antioxidant, immune-stimulating actions of melatonin is known. In our work we evaluated the antiproliferative role of melatonin on the mouse neuroblastoma N1E-115 clone C-1300 cell culture. Research conducted under cultivation in the serum-free ДМЕМ media with the addition of melatonin in the concentration range 10-6M to 10-5M. We showed that adding melatonin in the range of the indicated concentration caused inhibition of proliferation 25-35% of the cells and the induction of differentiation for 2-4 days of cultivation. Thus, it is shown that melatonin affects the change of proliferation, which to be appeared in the inhibition of the proliferative activity and induction of differentiation when cultured mouse neuroblastoma cells N1E-115 cells. We consider that melatonin can be used as an anticancer compound.