Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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RAT,S HEMOSTASIS SYSTEM IN DIFFERENT MODES ОF THE SINGLE HYPERTHERMICAL LOAD

Nikolaev V.Y. 1, 2 Shakhmatov I.I. 1, 2 Kiselev V.I. 1, 2 Vdovin V.M. 1, 2
1 Altai State Medical University
2 FGBI “Institute of Physiology and Fundamental Medicine” SB RAMS
The analysis of the state of hemostasis system in rats at different stages of becoming stage active excitation and height of the stage of thermal shock. We used at work Wistar line rats-males (64 species). Hyperthermia is modeled premise of laboratory animals at a certain time in thermal chamber (thermostat) the temperature inside +45оC. Stage of active excitation characterized hypercoagulation at all stages of coagulation, registered as to both ways of activation the initial phase and the destination phase of gemocoagulation. With this increase of fibrinogueń,s level aggravated befor trombotic stage readiness. Also the increase of the level of soluble fibrin monomers, which are used as markers of trombinemea, pointed to the formation of trombotic state. Changes identified in the hemostasis system at the stage of peak heat stroke, had a different focus. Longer term effects of hyperthermia accompanied by a reduction in the number of platelets and their aggregation activity. Coagulation hemostasis reacted to this effect by inhibition of the final stage clotting when the hight level of fibrinoguen.