Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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3D STRUCTURE MODELLING OF A CROMOPROTEIN FROM CONDYLACTIS GIGANTEA

Garkovenko A.V. 1 Pakhomov A.A. 1
1 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science
Information about protein structure plays a pivotal role in understanding of its functioning. In GFP-like proteins microenvironment of forming chromophore is of special interest in analysis of its synthesis mechanism. We have shown recently that homology modelling can be used for calculation of fluorescent proteins (FP) 3D structure. In the present work this method was applied for structure modelling of a chromoprotein from stony coral Condylactis giganea (cgCP). Amino-acids environment forms specific cavity for the chromophore, creates characteristic for FPs sterically tense states and plays a catalytic role. The data on the chromophore environment in cgCP allow to explain several peculiarities in its maturation.