Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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THE INFLUENCE OF CHRONIC VIRAL HEPATITIS C ON THE IMMUNE STATUS OF HIV-INFECTED INJECTING DRUG USERS

Reshetnikov I.V. 1
1 South Ural State Medical University
One of the most important ways of transfer of HIV in Russia still have the intravenous use of drugs. The number of the HIV-infected persons with an additional disease the chronic viral hepatitis C (CHCV) is very significantly owing to the general ways of transfer of HIV and HCV.Theinfluence of viral hepatitis C on the progress of HIV infection remains a disputable question. The features of the immune status of the HIV-infected injecting drug users (IDU) with CHCV were investigatedin our study. The system of extended white blood cell differential by flow cytometry CytoDiffwas used for this purpose. This system allows to count relative and absolute quantities of the following cellular populations: B-lymphocytes, T- and NK-cells (CD16+ and CD16-), monocytes (CD16+ and CD16-), mature neutrophils, eosinophils, basophiles, immature granulocytes, T- and B-cell precursors. Concentration of CD4+ lymphocytes was counted by the standard panel of monoclonal antibodies CD45-FITC/CD4-RD1/CD3-PC5. We carried the comparative analysis of two groups of HIV-infected patients – the IDU with an additional disease CHCV and the non-IDU without CHCV. The lower relative and absolute quantities of T-helpers were recordedin group of the IDU withcoinfectionHIV/HCV. Reliable distinctions in other leukocytes populations were not revealed.