Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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BIOLOGICAL ACTIVITY OF SELENORGANIC COMPOUND 1,5-DI-(M-NITROPHENYL)-3-SELENAPENTADION-1,5 ANALYSIS

Rusetskaya N.Y. 1
1 Saratov State Medical University n.a. V.I. Razumovsky
In work was studied the action of selenoorganic compound 1,5-di - (p-chlorphenil)-3-selenapentandion-1,5 on free radical oxidation, antioxidant status, functional state of tissues and metabolic processes at white not purebred mice. The given compound, on the one hand, had a small nephrotoxic effect (increased concentration of creatinine in blood plasma testifies about it), and, with another, compound possessed antioxidant activity in tissues of white mice, first of all, in a brain and lungs. The least antioxidant activity of the investigated compound is found in a liver and kidneys as xenobiotic detoxification occurs in a liver, and kidneys excrete the xenobiotics. Selenoorganic compound possessed high antioxidant activity that was expressed in considerable decrease in reactions the lipid peroxidation in a brain, lungs, erythrocytes and blood plasma.