Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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ANTIBACTERIAL ACTION OF TELLURORGANIC COMPOUND ON CLINICAL STRAINS OF ESCHERICHIA COLI

Rusetskaya N.Y. 1 Sarattsev A.V. 2 Drevko B.I. 3 Goroshinskaya I.A. 4 Borodulin V.B. 1
1 Saratov State Medical University n.a. V.I. Razumovsky
2 First Moscow State Medical University n.a. I.M. Sechenov
3 Saratov State Agrarian University n.a. N.I. Vavilov
4 Rostov Research Oncological Institute
In work was studied the antibacterial effect of compound 1,5-difenil-3-telluropentandion-1,5 in concentration 0,0001-1 mg/ml and at the incubation 30, 60, 90, 120, 150 minutes on clinical strains of Еscherichia coli extracted from patients with suppurative complications of traumatology and orthopedic hospital. The tellurorganic compound considerably suppressed the growth of colonies in concentration of 0,001-1 mg/ml. Antimicrobial activity of the compound was enhanced at the increase in its concentration and time of incubation, reaching a maximum in concentration of 0,1-1 mg/ml when growth of colonies is inhibited completely. The action mechanism of tellurorganic compound was caused by its low molecular weight, hydrophobic properties of a molecule and considerable toxicity thanks to what the studied compound can easily get through lipopolysaccharide layer of an external membrane of Gram-negative bacteria and operate as an effective antibacterial preparation.