science-review.ru
Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454
ISSN 2500-3399
ПИ №ФС77-57454
INFLUENCE OF INTRAMUSCULAR INTRODUCTION OF NANODIMENSIONAL PARTICLES OF COPPER ON BIOCHEMICAL INDICATORS OF BLOOD OF FEMALES OF RATS AT GESTATION
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The influence of intramuscular introduction of nanoparticles of copper on biochemical indicators of blood of females of rats at pregnancy is regarded. The purposes of research are determined. They are as follows: assessment of influence of nanodimensional particles on metabolic processes in rats’ organism during pregnancy due to biochemical blood indicators. Researches are executed on 40 white laboratory rats of the “Wistar” line at a gestation. Results of the made experiment are stated. It was established that the maximum concentration of nanoparticles led to pregnancy interruption on early terms. At introduction of nanoparticles in concentration 0,5 and 1 mg/kg pregnancy was prolonged. For the 20-th day of pregnancy fetus was viable without visible developmental anomalies. In all skilled groups there was a decrease in general protein, bilirubin in serums of blood. The greatest decrease is noted at copper introduction in concentration 2 mg/kg (the general protein is lowered by 1,5 times, bilirubin – by 2,5 times). Considerable decrease in level of triglycerides and cholesterol is revealed in the same group. Cholesterol is lowered twice, and level of triglycerides – by 8 times in comparison with the control. In the second and third skilled groups the level of amylase