Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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ROLE NONSPECIFIC IMMUNITY IN THE PROGRESSION OF MYELOMA DISEASE

Smirnova O.V. 1 Manchuk V.T. 1 Agilova Y.N. 1
1 FSBI «SRI Medical Problems of the North» RAMS
The authors studied the role of nonspecific immunity in the progression of multiple myeloma. With the help of the research revealed that the development of multiple myeloma in humans is accompanied by a change in the functional properties of peripheral neutrophils. As the disease progresses, an increase of spontaneous AFO production by neutrophils, as indices of spontaneous AFO production in patients with multiple myeloma at stage II and III significantly higher than the control group. Induced AFO production by neutrophils increased in all groups, with respect to the spontaneous production and control parameters, which proves the role of neutrophils, as the first line of nonspecific antimicrobial protection, but also as cytotoxic effectors against tumor cells