Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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THE STUDY OF ANTITUBERCULAR ACTIVITY OF 6-HYDROXI-2,3-DIMETHYL-6- TRIFLUORINEMETHYL-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]CHINOLINE-8-ONА

Stepanenko I.S. 1 Kotkin A.I. 1 Yamashkin S.A. 1 Borodulina M.V. 2 Ljamina E.L. 2 Rogozhina N.A. 2
1 Mordovian M.E.Yevseviev State Pedagocial Institute
2 State owned health care institution of the Republic of Mordovia «Republican TB dispensary»
In the research to identify the physiological activity of heterocyclic compounds series of indole and quinoline, we began to explore some of variously substituted pyrroloquinoline combining indole and quinoline fragment on biological activity. One of the compounds of this series is obtained and described by us 6-hydroxy-2,3-dimethyl-6- trifluoromethyl-6,7,8,9-tetrahydro-1H-pyrrolo[3,2-h]quinoline-8-on. The results showed that the test compound exhibits a broad spectrum of antimicrobial activity. As well study was conducted antitubercular activity of pyrroloquinoline. To determine the anti-TB activity was used the method of absolute concentrations in the environment Levinstein-Jensen In the experiment used the clinical strains of Mycobacterium tuberculosis repeatedly tested and sensitive to all anti- TB drugs. The analysis of the results showed that 6-hydroxy-2,3-dimethyl-6-trifluoromethyl-6,7,8,9-tetrahydro-1H-pyrrolo[3,2-h]quinoline-8-on is able to inhibit the growth and multiplication of Mycobacterium tuberculosis.