Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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CHANGES IN THE LEVEL OF BLOOD TUMOR MARKERS IN BRAIN METASTASES FROM BREAST CANCER

Frantsiyants E.M. 1 Komarova E.F. 1 Bandovkina V.A. 1 Plotnikova V.E. 1 Chugunova N.S. 1
1 Federal State Budgetary Institution “Rostov Research Oncological Institute” of Ministry of Health of Russian Federation
A study of content of S-100 protein, neuron-specific enolase (NSE) and Ca 15.3 in blood serum of women with menopause for ≥ 3 years having breast cancer Т2-3N0-1M0 (control group, n=20) and Т2-3N0-1M1-2 (main group, n=20) – patients with brain metastases from breast cancer – was performed by solid -phase immunoassay. All the studied markers possessed certain informativity and were detected in most cases in patients with brain metastases from breast cancer: 57-70% against 17% in control group for S-100; 65-70% against 50% for Ca 15.3, and 46-67% against 18% for NCE marker, and NCE and Ca15.3 concentration of the latter was 1,5 times and 4times higher in poor prognosis patients, respectively. It allows recommending of detection of the studied tumor markers for the control of results of treatment of patients with breast cancer.