Scientific journal
Scientific Review. Biological science
ISSN 2500-3399
ПИ №ФС77-57454

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CHARACTERIZATION OF THE BEHAVIOR OF THE ALCOHOL-PREFERRING RATS IN THE INSTALLATION «ELEVATED PLUS MAZE» AND THE CONTENT OF CATECHOLAMINES AFTER EXPOSURE TO THE STRESSOR

Leushkina N.F. 1 Fedorova A.M. 1 Akhmadeev A.V. 1
1 Bashkir State University
The object of the study were WAG/Rij rats with genotype A1/A1 on the locus Taq 1A gene D2 receptor after breeding on the preference of alcohol. As a stressor used five times daily audiogenic stimulation. Stress significantly increased the time of stay of rats in the dark compartment of labyrinth, as well as the duration and the number of episodes of grooming, that testifies to the formation of their anxiety. Comparison of the results of testing the behavior of rats in the “elevated plus maze” with a previously identified shifts in behavior in “open field” allows you to point to the inherent feature of these rats. It lies in the fact that anxiety is manifested formation of the active strategy of behavior. After exposure to stress loads content of dopamine in the Amygdala (high to stress) is reduced by 33 %. Unlike dopamine, in response to stress the content of norepinephrine increases by 17 %. Identified neurobiological features are of interest to study the mechanisms of formation of deviant behavior.